Hyperbaric oxygenation did not
improve recovery following exercise-induced muscle soreness.
Clinical bottom line:
1. No good evidence of a
significant beneficial effect of HBOT in exercise-induced muscle soreness.
2. Some suggestion that there may
be faster recovery of symptoms as measured on day 3.
Citation:
Germain G, Delaney J, Moore G,
Lee P, Lacroix V, Montgomery D. Effect of hyperbaric oxygen therapy on
exercise-induced muscle soreness. Undersea and Hyperbaric Medicine 2003;
30(2):135-145.
Lead author's name and fax: G.
Germain, McGill University, Montreal, Canada
Three-part Clinical Question:
For patients performing eccentric exercise, does the application of hyperbaric
oxygen therapy, compared to no specific intervention, result in any reduction in
symptoms or improved recovery from delayed onset muscle soreness?
Search Terms:
Delayed onset muscle soreness, eccentric exercise, muscle damage
The Study:
Non-blinded randomised controlled
trial with intention-to-treat unknown.
The Study Patients:
Healthy young adult volunteers with no recent history of quadriceps weight
training.
Control group:
(N = ?8; ?8 analysed): No treatment.
Experimental group: (N = ?8; ?8 analysed): 95% oxygen at 2.5ATA for 100 minutes at 1 hour, 6hours, 1 day and twice during second day post-exercise.
The Evidence: Non-event
outcomes only
|
Outcome |
Time
to outcome |
Method |
Test
stat |
P-value |
|
Muscle soreness (VAS) |
0
- 14 days |
2-way
ANOVA |
F
1.13 |
P
0.31 |
|
Plasma creatine kinase (IU) |
0
- 14 days |
2-way
ANOVA |
F
1.60 |
P
0.23 |
|
Peak torque at 180 degrees (Nm)
|
0
- 14 days |
2-way
ANOVA |
F
0.75 |
P
0.39 |
|
Outcome |
Control
group mean sd |
HBOT
group mean sd |
Difference |
95%
CI |
|
Peak torque at 1800 extension
on day 2 (Nm) |
110.2
+/- 34.1 |
97.9
+/-32.1 |
12.3 |
-23.216
to 47.816 |
Comments:
1. Number randomised to each arm
not known and 1 subject withdrawn at an unknown
time, from an unstated arm.
2. No power calculation or
discussion of effect important to exclude.
3. Treatment commenced early,
before onset of symptoms.
4. General testing of overall
differences between groups using ANOVA, rather than differences at each time is
appropriate.
Appraised by:
Mike Bennett Prince of Wales Hospital, Sydney ; Friday, 10 October
2003
Email: m.bennett@unsw.edu.au
Kill or Update By:
February
2005