|
1. Hyperbaric oxygenation was associated with
improvement in gross haematuria in the short term |
Citation/s:
Lewis AL, Hardy KR, Huang ET, Bolotin T, Clark JM, Thom SR. Hyperbaric oxygen
therapy decreases gross haematuria and improves quality of life in patients with
radiation cystitis. Undersea
and Hyperbaric Medicine 2005; 32(4)236
Three-part Clinical Question: For patients with radiation cystitis, does
hyperbaric oxygen therapy compared to standard approaches to treatment, result
in any reduction in haematuria, pain or other related symptoms?
Search Terms: Radiation, cystitis, haematuria
The Study:
Non-blinded randomised cross-over trial with intention-to-treat.
The Study Patients: Symptomatic radiation cystitis including gross
haematuria.
Control group (N = 26 ; 19 analysed): Standard therapy (no details) for
six weeks, then crossed over to HBOT arm.
Experimental group (N = 26 ; 19 analysed): 100% oxygen at an unspecified
pressure daily for six weeks, then crossed to standard arm.
The Evidence:
|
Outcome |
Time
to Outcome |
Control
group rate |
Hyperbaric
group rate |
Relative
risk reduction |
Absolute
risk reduction |
Number
needed to treat |
|
Resolution
of gross haematuria |
12
weeks |
0.12 |
0.54 |
368% |
0.42 |
2 |
|
95% Confidence Intervals: |
170% to 566% |
0.12 to 0.65 |
2 to 5 |
|||
|
Non-Event
Outcomes |
Time to
outcome/s |
Result |
|
Prostatitis severity survey |
12 weeks |
Improved after HBOT, but not statistically significant |
|
Quality of Life score |
12 weeks |
Better, P= 0.007 |
|
Long-term follow-up |
1.5 yrs |
Trends to improvement |
Comments:
1. Small study reported in abstract only
2. Cross-over design so that any results longer than six weeks do not represent
a randomised comparison
3. Little details of the outcomes measured and the figures above remain
speculative to some degree
Appraised by: Mike Bennett, Sydney; Wednesday, 11 July 2007
Email: m.bennett@unsw.edu.au
Kill or Update By: July 2008