Hyperbaric
oxygenation improved transcutaneous oximetry and other vascular parameters in
diabetic feet
Clinical Bottom Line:
1.
No clinical results given
2.
Transcutanoeus oxygen readings improved over a course of HBOT
Appraised
by: Mike Bennett, Diving and Hyperbaric
Medicine, Prince of Wales Hospital, Sydney; Monday, 13 August 2001
Clinical
Scenario: An insulin dependent diabetic
with a lesion on the foot presented for hyperbaric therapy.
Three-part
Question: For patients with diabetic foot
ulcers, does the additional administration of hyperbaric oxygen, compared to a
standard care regime alone, result in any improvement in clinical healing or
interim indicators of improved vascular state?
Search
Terms: Diabetes mellitus, chronic
ulcers
The
Study:
?Blinded randomised controlled
trial, intention-to-treat unknown.
Known diabetics with Wagner
Grade 0 to 2 lesions of the feet.
Control group (N = 12; 12
analysed): Treated for diabetic feet, details unknown.
Experimental group (N = 17; 17
analysed): Same treatment as controls but with addition of HBO, dose unknown.
The
Evidence:
Non-Event Outcomes Time to
outcome Control
group Hyperbaric
group P-value
Transcutaneous
oximetry
30 treatments
36 +-21
58 +-21
<0.01
(mmHg)
HbA1C
(%)
30 treatments
9.3 +-4.3
6.6 +-1.7
<0.01
Laser-doppler
perfusion (flux) 30
treatments
26 +-4
36 +-7
<0.01
Ankle
Brachial Index
30 treatments
NS
Comments:
1. No clinical outcome
information
2. Abstract only, few details
Expiry date: September 2004
References:
1. Lin TF, Chen SB, Niu KC. The
vascular effects of hyperbaric oxygen therapy in treatment of early diabetic
foot. Undersea and Hyperbaric Medicine 2001; 28 (Suppl):67.
