Hyperbaric
oxygenation may have reduced the incidence of sepsis associated with thermal
burns.
Clinical
Bottom Line:
1.
Apparent reduction in the incidence of sepsis following thermal burns with the
addition of hyperbaric oxygenation to a therapeutic regime.
Citation:
Xu
N, Li Z, Luo X. [Effects of hyperbaric oxygen therapy on the changes in serum
sIL-2R and Fn in severe burn patients]. Zhonghua Zheng Xing Shao Shang Wai Ke Za
Zhi 1999; 15(3):220-223.
Three-part
Clinical Question: For patients with thermal burns, does the addition of
hyperbaric oxygenation to a standard therapeutic regimen reduce the incidence of
burn infection?
Search
Terms: Hyperbaric oxygenation, Burns thermal
The
Study:
Non-blinded
randomised controlled trial with intention-to-treat unknown.
The
Study Patients: Patients with
>30% body surface area burns (or 3rd degree >10%BSA).
Control
group (N = 17): Not stated
Experimental
group (N = 25: HBO regimen not stated
The
Evidence:
|
Non-Event Outcomes |
Time
to outcome |
Control
group |
HBO
group |
P-value |
|
Incidence of sepsis |
35
days |
? |
Reduced |
P
<0.05 |
|
Serum soluble interleukin 2 receptor |
35
days |
? |
Not
increased |
P
<0.05 |
|
Plasma fibronectin |
35
days |
? |
Not
decreased |
P
< 0.01 |
Comments:
1.
Abstract only, little data given.
2.
No details of randomization method, control therapy or hyperbaric schedule.
3.
Clinical impact unknown.
4.
Soluble interleukin 2 receptors in the serum are increased and plasma
fibronectin is decreased in patients with burns and they are both apparently
markers for burn infection. These markers were not significantly different in
HBO treated subjects when compared to healthy, non-burned controls.
5.
Article in Chinese, not yet available in translation.
Appraised
by:
Mike Bennett and Juliette Leverment, Hyperbaric Medicine, Prince of Wales
Hospital, Sydney ; Monday, 9 December 2002
Email:
m.bennett@unsw.edu.au
Kill
or Update By: December 2004